To promote supramolecular assembly from fundamental research of aggregates at molecular level to application of bulk materials at macroscopic scale, we mainly focus on the research topic of supramolecular materials. We are among the early groups to start the work about “Macroscopic Supramolecular Assembly” by investigating the supramolecular assembly and diffusion of building blocks with features size beyond microscale. On the aspect of assembly mechanism, we try to answer two fundamental questions of “What kind of building blocks could achieve macroscopic assembly?” and “What kind of supramolecular interactions could be used for macroscopic assembly?”. We propose a basic design rule of macroscopic building block is to possess highly flowable surface with self-healing properties and a “double locking” strategy to realize versatile macroscopic supramolecular assembly. On the aspect of improve the spontaneity of assembly processes, we propose the concept of “functionally cooperative smart devices” to realize the controlled locomotion of macroscopic objects; by further combining the locomotion and assembly process, we have developed several new methods for macroscopic supramolecular self-assembly. Furthermore, we have exploited the application of macroscopic supramolecular assembly in the fields of tissue scaffolds, bio-chips etc. Till now, we have 76 articles on Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater., NPG Asia Mater., Small, J. Mater. Chem etc., 4 approved patents; the citation (excluding self-citation) reaches 3832.